Bee makes his first appearance as a wounded puppy Majin Buu encounters. Buu heals the dog, prompting the beginning of a friendship between the two. Soon after, even Mr. Satan befriends the pup. While playing catch with Buu, the anarchist Van Zant arrives and shoots Bee. Buu's attempt to revive Bee is a success, but he loses himself in his rage when the assailant shoots Mr. Satan as well. This causes Buu to become literally "steaming mad," and through this steam escapes his violent persona, Evil Buu.
At the climax of the Majin Buu Saga, Bee and Mr. Satan encounter Gohan, Piccolo, Goten, Trunks and Super Buu. During this time, the usually ridiculous personality of Mr. Satan subsides in favor of a more caring side of the martial artist, as he makes sure that Bee is safe from Vegito's conflict with Super Buu.Bee's final appearances in the series are during the last three episodes of Dragon Ball Z, where he has aged significantly, now being placed as around 10 years of age or so. After the conclusion of Dragon Ball Z, Bee continues to live with Mr. Satan and Majin Buu; during the film Wrath of the Dragon, he is also shown being looked after by Bulma's family. Bee's lack of an appearance in Dragon Ball GT has been reasoned by two possibilities. The first explanation may be that Bee passed away in the ten year gap between Z and GT, as the dog was already very old in Dragon Ball Z's final three episodes, and dogs living to the age of 20 is relatively unheard of in the real word, but may of course be different in the Dragon World. The second possibility may be that Bee simply spent the entirety of GT in Satan's home, except for when Goku transports the Earth's population to Planet Plant prior to the destruction of Earth (In which case, he was with Mr. Satan on Planet Plant.).
Also, while he does not physically appear during Dragon Ball GT, Bee does appear in promotional artwork for the series, where he is pictured alongside Mr. Satan and Majin Buu following Emperor Pilaf's wish that reverts Goku's body to child-form. He also appears in the 3rd Ending GT in the ending group shot featuring the supporting and major cast of the series that have played some type of role at some point in the series. These two minor appearances could indicate that Bee is possibly still alive, just not featured.